Midazolam (Versed)

Class: Short-acting benzodiazepine CNS depressant


Midazolam HCl is a water-soluble benzodiazepine that may be administered for conscious sedation to relieve apprehension or impair memory before endotracheal or nasotracheal intubation.

Onset & Duration

Onset: 1-3 min (IV); dose dependent

Duration: 2-6 hr; dose dependent


Premedication for tracheal intubation


Hypersensitivity to midazolam Glaucoma

Shock Coma Alcohol intoxication

Overdose Depressed vital signs Concomitant use of barbiturates, alcohol, narcotics, or other CNS depressants

Adverse Reactions

Hiccough Cough Over-sedation Pain at the injection site

Nausea and vomiting Headache Blurred vision

Fluctuations in vital signs Hypotension

Respiratory depression Respiratory arrest

Drug Interactions

Sedative effect of midazolam may be accentuated by concomitant use of barbiturates, alcohol, or narcotics (it should therefore not be used in patients who have taken CNS depressants).

How Supplied

2-, 5-,10-ml vials (1 mg/ml)

1-, 2-, 5-,10-ml vials (5 mg/ml)

Dosage and Administration

Adult: 2-2 5 mg slow IV (over 2-3 min); may be repeated if necessary in small increments (total maximum dose not to exceed 0.1 mg/kg)

Pediatric: Not recommended

Special Considerations

Pregnancy safety: Category D.

Administer immediately before the intubation procedure.

Provide continuous monitoring of respiratory and cardiac function.

Have resuscitation equipment and medication readily at hand. Never administer medication as IV bolus.